1. CeMs LAB @ SCI CHULA

ABOUT CE
 

CEMS LAB was first established as Shrimp Molecular Biology and Genomics Laboratory by Chulalongkorn University in 2003. In 2004, BIOTEC entered in a Memorandum of Understanding with Chulalongkorn University to co-support the activities.....

 

The Center of Excellence for Molecular Biology and Genomics of Shrimp was first established as Shrimp Molecular Biology and Genomics Laboratory by Chulalongkorn University in 2003. In 2004, BIOTEC entered in a Memorandum of Understanding with Chulalongkorn University to co-support the activities of Shrimp Molecular Biology and Genomics Laboratory. The Lab was promoted to the status of Center of Excellence by Chulalongkorn University in 2008.


-  Genomic research for increase culture efficiency of shrimp: the study of  

     genes and proteins associated with disease resistance

-   Functional genomic approach to identify candidate genes and proteins     

     responding to pathogens in black tiger shrimp Penaeus monodon 

-    Molecular mechanisms of immune responses in shrimp

-   Genetic and molecular markers for selective breeding at the molecular level

     (growth, disease resistance, stress)

-   Characterization and application of antimicrobial peptides from the black tiger

     shrimp P. monodon

-   Study of antiviral immunity of the black tiger shrimp, P. monodon :

     Characterization of a viral responsive gene and identification of miRNAs  

     involved in WSSV infection

-   Molecular mechanisms of melanization/prophenoloxidase system in response

     to bacterial and viral pathogen infection in shrimp

-   Development of recombinant probiotics for the expression of shrimp

     antimicrobial peptide and their use in disease control in shrimp aquaculture

-    Microplate reader with multi-detection system

-    FPLC system

-    Real time PCR

-    Environmental controlled room for cell and tissue culture

-    Fluorescence microscope with digital image gallery and processing

     -   Digital microscope and image analysis program

-  The Shrimp ETS database providing a useful genetic resource to identify

     tissue-specific genes and genes responded to infection and stress, available

     for download at http://pmonodon.biotec.or.th  

-   Development of cDNA microarray chip comprised of 9990 different ESTs

     obtained from the P. monodon EST project was employed to identify viral

    (white spot and yellow head viruses) and bacterial (Vibrio harveyi) responsive genes in the hemocytes of P. monodon

-   Discovery the role of anti-lipopolysaccharide factor from the black tiger shrimp, 

     P. monodon, in protection from white spot syndrome virus (WSSV) infection

-  A novel viral responsive proteinHemocyte Homeostasis-Associated Protein (HHAP)” in the black tiger shrimp, P. monodon , and its role in the response of shrimp to white spot syndrome virus (WSSV) infection

-    Identification of the relevant genes involving shrimp immunity

- Expression profile of immune-related genes; cathepsins, crustin, penaeidin

-  Characterization of antimicrobial peptides against shrimp pathogens such as Penaeidin, Crustin, Antilipopolysaccharide factor.

-  Molecular characteristics of the genes in the proPO system of the penaeid shrimp P. monodon

-    A proposed mechanism for the activation of the proPO cascade in the penaeid shrimp P. monodon

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